Abstract: Fucoxanthin is a bioactive compound that is a kind of natural carotenoid. Fucoxanthin\nis known to protect against UV-B-induced cell damage in hairless mice, even though it is\nphysiochemically unstable to heat and acid due to its polyunsaturated structure, indicating that\nfucoxanthin possesses a low bioavailability, and this disadvantage limits its application in the\ncosmetic industry. Solid lipid nanoparticle (SLN) systems are known to be suitable as carriers for\nsunscreen agents. In this research work, the sunscreen-boosting effect of SLN, as a deliverer of\nfunctional ingredient, especially fucoxanthin, has been developed and evaluated by comparing the\nsunburn protection factors (SPF) of macroemulsion (cream and lotion type) and an SLN formula\ncontaining various kinds of sunscreen agents, respectively. Several results such as stability test,\nparticle size, DSC analysis, and X-ray analysis show that the SLN formula loading fucoxanthin has\nthe possibility of being a stable and high-functioning ingredient delivery system. Moreover, the\nSLN formula has shown a higher SPF value than others, meaning that the SLN formula exhibits a\ngood sunscreen-boosting effect. This study indicates that the use of SLN as a carrier enhanced the\nbioavailability of fucoxanthin and shows that SLN could be a promising carrier for the production of\nsunscreen products by allowing the scaling-up of production.
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